We investigated how vitamin C, also known as ascorbic acid, might impact autoimmune disorders like rheumatoid arthritis. Through a study involving a mouse model of collagen-induced arthritis, we administered vitamin C or a placebo solution and observed the effects on the immune response and disease progression.
Notably, the research showed that mice given vitamin C experienced a significant delay in the onset of arthritis and a reduction in disease severity. This suggests that vitamin C can play a critical role in managing autoimmune conditions by minimizing the production of autoantibodies, which are harmful antibodies that mistakenly attack the body's tissues.
Our findings revealed that vitamin C reduced the number of plasma cells and decreased antibody production in response to immunization. This indicates that vitamin C influences the immune system's response at a cellular level, helping to prevent the emergence of autoreactive plasma cells. We also discovered that the mechanism behind this effect involved inhibiting the Stat3 signaling pathway, leading to less activation of autoreactive immune components.
Ultimately, these results highlight the potential of vitamin C not just as a nutrient, but as a strategic tool in managing autoimmune disorders. By simply supplementing with vitamin C, there may be a way to intervene positively in the progression of diseases like rheumatoid arthritis.
Read More
9
Vitamin C helps rheumatoid arthritis
Vitamin C alleviates rheumatoid arthritis by modulating gut microbiota balance.
We explored how vitamin C supplementation might affect rheumatoid arthritis (RA), an autoimmune disorder that causes chronic inflammation. Our research focused on whether vitamin C could help restore balance in gut microbiota, which previous findings indicated could worsen RA by breaking down vitamin C.
Using collagen-induced arthritis (CIA) mouse models, we conducted a series of tests, including biochemical and microbiological evaluations. The outcome was promising: vitamin C not only helped rebalance the gut microbiota but also reduced inflammation typical of RA, as seen in the notable decrease in pro-inflammatory cytokines like IL-6 and TNF-α.
In essence, the treatment with vitamin C showed significant benefits in alleviating RA symptoms in our study. These findings suggest that vitamin C could be a useful therapeutic option for managing rheumatoid arthritis effectively by targeting gut health.
Read More
8
Vitamin C may lower hypothyroidism risk
Association between total vitamin C intake and hypothyroidism among Hashimoto thyroiditis: National Health and Nutrition Examination Survey, 2007-2012.
We aimed to understand how vitamin C intake influences hypothyroidism in patients with Hashimoto thyroiditis (HT). Through a detailed analysis of data collected in the National Health and Nutrition Examination Survey from 2007 to 2012, we found notable results that shed light on this relationship.
Our study involved looking at various participants categorized by their total vitamin C intake. We discovered a significant negative correlation between the amount of vitamin C consumed and the likelihood of developing hypothyroidism in those with HT. In essence, individuals drinking higher amounts of vitamin C—up to 1,258.9 mg per day—exhibited a lower probability of experiencing hypothyroidism compared to those with minimal intake.
Furthermore, this connection remained apparent even when we examined different age groups and genders, indicating that vitamin C could play a protective role against hypothyroidism related to Hashimoto's thyroiditis. Thus, our findings suggest that enhancing vitamin C consumption might be a beneficial strategy for those managing this autoimmune condition.
Read More
Most Useful Reviews
9
Improved skin health
5 people found this helpful
Solaray is of high quality! It greatly aids sleep disorders, strengthens mucous membranes, and enhances skin complexion. I strongly believe all Solaray’s supplements are outstanding. This vitamin C's formulation, including rosehip and acerola, is effective and is gently released over 12 hours. It helped me overcome a severe sleep disorder lasting nine and a half years. Thanks to its antioxidant property, I also enjoy improved immunity and have stronger mucous membranes, resulting in fewer colds. My skin glows daily—I'm truly grateful.
Read More
7.5
Milder cold symptoms
1 people found this helpful
I take two capsules a day due to my family's autoimmune disorder history. It's vital for its antioxidant properties. When my child gets a cold, the symptoms are considerably milder when we take this with zinc for immunity.
Read More
7.5
Protective effects
1 people found this helpful
This excellent product allows me to take a capsule every 2-3 days. It effectively protects against ARVI and influenza, making it ideal for preventive use. I will order it again.
We investigated how vitamin C, also known as ascorbic acid, might impact autoimmune disorders like rheumatoid arthritis. Through a study involving a mouse model of collagen-induced arthritis, we administered vitamin C or a placebo solution and observed the effects on the immune response and disease progression.
Notably, the research showed that mice given vitamin C experienced a significant delay in the onset of arthritis and a reduction in disease severity. This suggests that vitamin C can play a critical role in managing autoimmune conditions by minimizing the production of autoantibodies, which are harmful antibodies that mistakenly attack the body's tissues.
Our findings revealed that vitamin C reduced the number of plasma cells and decreased antibody production in response to immunization. This indicates that vitamin C influences the immune system's response at a cellular level, helping to prevent the emergence of autoreactive plasma cells. We also discovered that the mechanism behind this effect involved inhibiting the Stat3 signaling pathway, leading to less activation of autoreactive immune components.
Ultimately, these results highlight the potential of vitamin C not just as a nutrient, but as a strategic tool in managing autoimmune disorders. By simply supplementing with vitamin C, there may be a way to intervene positively in the progression of diseases like rheumatoid arthritis.
Read More
9
Vitamin C aids rheumatoid arthritis treatment
A bioactive and biodegradable vitamin C stearate-based injectable hydrogel alleviates experimental inflammatory arthritis.
This study investigated the effects of a specially formulated hydrogel that combines vitamin C with 9-aminoacridine (9AA) on a model of rheumatoid arthritis (RA). We saw that this hydrogel is not only bioactive but also biodegradable, making it a potential candidate for treating this chronic autoimmune condition.
Our research showed that the combination of vitamin C—specifically in the form of 6-stearoyl-L-ascorbic acid—and 9AA could significantly reduce inflammation in our experimental model. By acting on specific pathways, such as the NR4A1 nuclear receptor, the hydrogel appears to exert anti-inflammatory effects that could alleviate some symptoms of arthritis.
We also noted that vitamin C plays a dual role by promoting collagen production, which is essential for joint health. This is crucial since RA leads to the deterioration of joint tissues.
In conclusion, our findings suggest that using this hydrogel could represent a more effective treatment strategy for RA compared to existing options. With its ability to reduce inflammation and promote tissue healing, this innovative approach offers hope to those suffering from this debilitating condition.
Read More
9
Vitamin C helps rheumatoid arthritis
Vitamin C alleviates rheumatoid arthritis by modulating gut microbiota balance.
We explored how vitamin C supplementation might affect rheumatoid arthritis (RA), an autoimmune disorder that causes chronic inflammation. Our research focused on whether vitamin C could help restore balance in gut microbiota, which previous findings indicated could worsen RA by breaking down vitamin C.
Using collagen-induced arthritis (CIA) mouse models, we conducted a series of tests, including biochemical and microbiological evaluations. The outcome was promising: vitamin C not only helped rebalance the gut microbiota but also reduced inflammation typical of RA, as seen in the notable decrease in pro-inflammatory cytokines like IL-6 and TNF-α.
In essence, the treatment with vitamin C showed significant benefits in alleviating RA symptoms in our study. These findings suggest that vitamin C could be a useful therapeutic option for managing rheumatoid arthritis effectively by targeting gut health.
Read More
9
Ascorbyl palmitate targets inflammation
Ascorbyl palmitate ameliorates inflammatory diseases by inhibition of NLRP3 inflammasome.
We examined the effects of ascorbyl palmitate (AP), a derivative of vitamin C, on the NLRP3 inflammasome, which plays a significant role in various autoimmune disorders. The research shows that AP effectively inhibits the activation of this inflammasome, suggesting it could be a powerful tool in managing inflammation-driven diseases.
Notably, AP showed greater potency and specificity in inhibiting the inflammasome compared to regular vitamin C. It appears to achieve this by scavenging harmful reactive oxygen species and disrupting key interactions necessary for inflammasome assembly.
Furthermore, we found that AP exhibited more pronounced protective effects in models of systemic inflammation and conditions like colitis and autoimmune encephalomyelitis than standard vitamin C treatments. This strengthens the case that AP could be a viable therapeutic option for combating NLRP3-driven diseases, presenting an exciting avenue for further research and potential clinical applications.
Read More
9
Vitamin C's Role in Inflammation
Rheumatologic manifestations with elevated levels of IL-6, IL-17A, and IL-23 in a patient with scurvy.
We observed a fascinating case involving an 11-year-old boy suffering from symptoms of scurvy, a condition arising from severe vitamin C deficiency. This boy had multiple issues, including iron-deficiency anemia, symptoms resembling bone infections, and muscle inflammation, particularly in his legs. His selective diet, likely due to a mild developmental disorder, led to a significant deficiency in vitamin C.
After he was diagnosed, we administered intravenous and oral vitamin C, which remarkably eased his joint and muscle pain within just a week. Following four months of supplementation, he showed complete recovery with no lingering symptoms or abnormal lab findings.
Notably, we found high levels of certain pro-inflammatory markers, specifically interleukin-6, IL-17A, and IL-23, likely linked to an immune response involving T-helper 17 cells. This association presents an intriguing insight into the inflammatory processes that might be involved in scurvy and, potentially, in other autoimmune disorders.
Our observations hint that vitamin C might play a pivotal role in addressing inflammation linked to autoimmune conditions, paving the way for enhanced understanding and treatment options in the future.
Solaray is of high quality! It greatly aids sleep disorders, strengthens mucous membranes, and enhances skin complexion. I strongly believe all Solaray’s supplements are outstanding. This vitamin C's formulation, including rosehip and acerola, is effective and is gently released over 12 hours. It helped me overcome a severe sleep disorder lasting nine and a half years. Thanks to its antioxidant property, I also enjoy improved immunity and have stronger mucous membranes, resulting in fewer colds. My skin glows daily—I'm truly grateful.
Read More
7.5
Milder cold symptoms
1 people found this helpful
I take two capsules a day due to my family's autoimmune disorder history. It's vital for its antioxidant properties. When my child gets a cold, the symptoms are considerably milder when we take this with zinc for immunity.
Read More
7.5
Protective effects
1 people found this helpful
This excellent product allows me to take a capsule every 2-3 days. It effectively protects against ARVI and influenza, making it ideal for preventive use. I will order it again.
Read More
6
Potent immunity support
I've taken vitamin C for decades, and this particular brand is the most effective for keeping colds and flu at bay. Surprisingly, it works better for me than other brands with more bioflavonoids. When I was unwell in the past, I had to take a lot to feel better, which underscores the importance of this vitamin in managing my health.
Read More
7.5
Effective immunity booster
1 people found this helpful
I love this vitamin C! It's essential for my family during COVID-19. Other brands offer much lower doses. The slow-release feature is crucial for me. After I started taking this, my temperature normalised in three days. It's great for both prevention and treatment!
An autoimmune disorder occurs when the body's immune system mistakenly attacks its own healthy cells and tissues, believing them to be foreign invaders, such as bacteria or viruses. This reaction can lead to inflammation, tissue damage, and impaired function of the affected organs. There are over 80 known autoimmune diseases, including rheumatoid arthritis, lupus, multiple sclerosis, and type 1 diabetes, each with its own specific symptoms and treatment options. The exact cause of these disorders is still unclear, but a combination of genetic, environmental, and hormonal factors is believed to play a role in their development.
Diagnosis of autoimmune disorders often involves a combination of physical examinations, assessment of symptoms, blood tests, and imaging studies to evaluate organ involvement. Treatment typically focuses on managing symptoms and controlling the immune response using medications such as corticosteroids, immunosuppressants, and biologics. In addition to medication, lifestyle modifications, such as stress management and a balanced diet, can be beneficial in managing symptoms. If you suspect you have an autoimmune condition, it's important to consult a healthcare professional for proper evaluation and tailored treatment options.
Vitamin C, also known as ascorbic acid, is a water-soluble vitamin that plays a critical role in numerous bodily functions. As an essential nutrient, it contributes to the growth and repair of tissues in the body, and it is vital for the production of collagen, an important protein that helps maintain skin, cartilage, tendons, ligaments, and blood vessels. Additionally, Vitamin C acts as a powerful antioxidant, which means it helps combat free radicals—unstable molecules that can cause oxidative stress and contribute to various chronic diseases.
Moreover, Vitamin C enhances iron absorption from plant-based foods, making it a vital component for those following vegetarian or vegan diets. While many people get sufficient Vitamin C from a well-balanced diet that includes fruits and vegetables like oranges, strawberries, kiwi, broccoli, and bell peppers, some individuals might require supplementation. It's generally recommended to stay within the daily intake guidelines, as excessive consumption can lead to gastrointestinal disturbances. Overall, Vitamin C is not just a skincare celebrity—it's a fundamental part of maintaining overall health and well-being.
Based on user reviews, the timeframe for seeing results from this supplement can vary widely among individuals. Some users have reported experiencing positive effects within as little as three days. For instance, one reviewer noted that their temperature normalized after starting this vitamin C supplement and that it played a crucial role in both prevention and treatment of their illness Read Review. Others, however, seemed to incorporate it into a longer regimen, highlighting its long-term benefits for immunity and overall health, which may be more about gradual improvement rather than immediate changes.
Additionally, consistent use has been noted as a strategy by users with autoimmune disorders. One reviewer mentioned taking two capsules daily not only for their own health but also as a preventive measure for their child, emphasizing the importance of regular intake for better outcomes Read Review. Overall, while some users may see quick results, others report a need for sustained use to fully appreciate the supplement's benefits.
The current scientific research suggests that vitamin C may play a beneficial role in the management of several autoimmune disorders. Studies indicate that vitamin C not only provides anti-inflammatory benefits but also helps mitigate the severity of conditions such as rheumatoid arthritis (RA) and Hashimoto's thyroiditis. For instance, a study using a mouse model found that vitamin C administration led to reduced disease severity and diminished autoantibody production, signifying its potential impact on autoimmune conditions [3]. Further research has explored the negative correlation between vitamin C intake and the risk of hypothyroidism in patients with Hashimoto's, indicating that higher consumption of this vitamin might offer protective effects [2].
Additionally, a review of multiple studies showed that vitamin C could modulate immune responses and combat oxidative stress associated with autoimmune diseases [4]. This is particularly relevant in disease management strategies, as vitamin C may enhance conventional treatment protocols while directly influencing the immune system's behavior against autoantigens. However, it is essential to acknowledge that while these findings are promising, many studies have limitations and further research is needed to establish definitive therapeutic guidelines regarding vitamin C supplementation for autoimmune conditions.
Users have reported a variety of improvements in their symptoms while using this vitamin C supplement. Many have noted significant enhancements in their overall health, particularly concerning immunity and cold prevention. One reviewer shared that after incorporating this product, they experienced fewer colds and improved mucous membrane strength, stating, "I also enjoy improved immunity and have stronger mucous membranes, resulting in fewer colds" Read Review. For those with autoimmune concerns, another user highlighted that their child experienced milder cold symptoms when taking the supplement alongside zinc, indicating a noticeable positive impact on their wellness Read Review.
Furthermore, some users have indicated that the formulation's slow-release mechanism has been beneficial in managing ailments effectively. One reviewer noted that their temperature normalized just three days after starting the vitamin C regimen, emphasizing its effectiveness for both prevention and treatment Read Review. Overall, while individual results may vary, many users express a strong sense of satisfaction regarding the supplement's ability to enhance their resistance to illnesses and support their health.
Users have reported that combining this vitamin C supplement with other products, particularly zinc, has led to noticeable improvements in managing autoimmune disorders. One mother mentioned that her child's cold symptoms became considerably milder when this vitamin C was taken alongside zinc, highlighting the synergistic effect of combining these supplements for enhanced immunity Read Review. This suggests that users with autoimmune concerns may benefit from a multi-supplement approach, especially when dealing with colds and flu.
Furthermore, the supplement's formulation, which is designed for slow release, garnered positive feedback from users who appreciate its sustained effects over time. One user noted the significant benefits in their immune response after starting this vitamin C regimen, asserting its importance not just as a standalone supplement, but as part of a broader health strategy for those with autoimmune issues Read Review. The combination of nutrients appears to fortify users' defenses against illness, making this vitamin C a worthwhile consideration for anyone grappling with an autoimmune disorder.
Users have reported varying doses for Vitamin C when addressing autoimmune disorders, with a general emphasis on the importance of tailored intake based on individual health needs. One user mentioned they take two capsules daily as a preventative measure, particularly due to a family history of autoimmune disorders, highlighting its vital antioxidant properties in boosting immunity during illness Read Review. Another user indicated a more flexible approach, taking a capsule every 2-3 days, which they found effective for protection against common illnesses like ARVI and influenza Read Review.
Though some users have varying routines, the consensus appears to support a consistent intake of Vitamin C, particularly under circumstances of illness or as a preventive measure. One user emphasized that they found significant benefits after adjusting their intake, relating it back to the management of their health during periods of illness Read Review. This underscores the notion that the right dosage can be quite personal, possibly dependent on the individual's health status and the specific autoimmune challenges faced.
7.5
Effective immunity booster
1 people found this helpful
I love this vitamin C! It's essential for my family during COVID-19. Other brands offer much lower doses. The slow-release feature is crucial for me. After I started taking this, my temperature normalised in three days. It's great for both prevention and treatment!
7.5
Milder cold symptoms
1 people found this helpful
I take two capsules a day due to my family's autoimmune disorder history. It's vital for its antioxidant properties. When my child gets a cold, the symptoms are considerably milder when we take this with zinc for immunity.
9
Improved skin health
5 people found this helpful
Solaray is of high quality! It greatly aids sleep disorders, strengthens mucous membranes, and enhances skin complexion. I strongly believe all Solaray’s supplements are outstanding. This vitamin C's formulation, including rosehip and acerola, is effective and is gently released over 12 hours. It helped me overcome a severe sleep disorder lasting nine and a half years. Thanks to its antioxidant property, I also enjoy improved immunity and have stronger mucous membranes, resulting in fewer colds. My skin glows daily—I'm truly grateful.
7.5
Protective effects
1 people found this helpful
This excellent product allows me to take a capsule every 2-3 days. It effectively protects against ARVI and influenza, making it ideal for preventive use. I will order it again.
6
Potent immunity support
I've taken vitamin C for decades, and this particular brand is the most effective for keeping colds and flu at bay. Surprisingly, it works better for me than other brands with more bioflavonoids. When I was unwell in the past, I had to take a lot to feel better, which underscores the importance of this vitamin in managing my health.
9
Vitamin C impacts autoimmune response
Ascorbic acid alleviates rheumatoid arthritis by inhibiting the production of autoantibodies.
We investigated how vitamin C, also known as ascorbic acid, might impact autoimmune disorders like rheumatoid arthritis. Through a study involving a mouse model of collagen-induced arthritis, we administered vitamin C or a placebo solution and observed the effects on the immune response and disease progression.
Notably, the research showed that mice given vitamin C experienced a significant delay in the onset of arthritis and a reduction in disease severity. This suggests that vitamin C can play a critical role in managing autoimmune conditions by minimizing the production of autoantibodies, which are harmful antibodies that mistakenly attack the body's tissues.
Our findings revealed that vitamin C reduced the number of plasma cells and decreased antibody production in response to immunization. This indicates that vitamin C influences the immune system's response at a cellular level, helping to prevent the emergence of autoreactive plasma cells. We also discovered that the mechanism behind this effect involved inhibiting the Stat3 signaling pathway, leading to less activation of autoreactive immune components.
Ultimately, these results highlight the potential of vitamin C not just as a nutrient, but as a strategic tool in managing autoimmune disorders. By simply supplementing with vitamin C, there may be a way to intervene positively in the progression of diseases like rheumatoid arthritis.
8
Vitamin C may lower hypothyroidism risk
Association between total vitamin C intake and hypothyroidism among Hashimoto thyroiditis: National Health and Nutrition Examination Survey, 2007-2012.
We aimed to understand how vitamin C intake influences hypothyroidism in patients with Hashimoto thyroiditis (HT). Through a detailed analysis of data collected in the National Health and Nutrition Examination Survey from 2007 to 2012, we found notable results that shed light on this relationship.
Our study involved looking at various participants categorized by their total vitamin C intake. We discovered a significant negative correlation between the amount of vitamin C consumed and the likelihood of developing hypothyroidism in those with HT. In essence, individuals drinking higher amounts of vitamin C—up to 1,258.9 mg per day—exhibited a lower probability of experiencing hypothyroidism compared to those with minimal intake.
Furthermore, this connection remained apparent even when we examined different age groups and genders, indicating that vitamin C could play a protective role against hypothyroidism related to Hashimoto's thyroiditis. Thus, our findings suggest that enhancing vitamin C consumption might be a beneficial strategy for those managing this autoimmune condition.
7
Vitamin C's potential in autoimmune treatment
Vitamin C Supplementation in the Treatment of Autoimmune and Onco-Hematological Diseases: From Prophylaxis to Adjuvant Therapy.
We explored the potential of vitamin C as a treatment option for autoimmune disorders, particularly focusing on its benefits for conditions like Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA). Our review of existing literature revealed a growing body of evidence suggesting that vitamin C supplementation can positively influence immune responses, which may help in managing these diseases.
The research indicates that vitamin C regulates the cytokine environment, which is essential for maintaining a balanced immune system. By modulating the immune response to autoantigens, vitamin C can potentially lessen the harmful effects of these autoimmune disorders. Furthermore, the antioxidant properties of vitamin C play a role in managing oxidative stress, a factor often associated with autoimmune conditions.
We also noted that vitamin C might enhance the effects of conventional therapies, such as chemotherapy and radiation treatment, when applied to hematological neoplasms. This suggests that vitamin C could serve as a beneficial adjuvant in standard treatment protocols, although its isolated effects on autoimmune diseases are still being understood.
References
Zhang H, Zhang Y, Zhang Y, Wei H, Jin S, et al. Combination of inorganic nitrate and vitamin C prevents collagen-induced arthritis in rats by inhibiting pyroptosis. Food Funct. 2025;16:673. 10.1039/d4fo03096f
Chen L, Mao Y, Chen G. Association between total vitamin C intake and hypothyroidism among Hashimoto thyroiditis: National Health and Nutrition Examination Survey, 2007-2012. Br J Nutr. 2024;132:1575. 10.1017/S0007114524001715
Yin Y, Wu S. Ascorbic acid alleviates rheumatoid arthritis by inhibiting the production of autoantibodies. Cell Commun Signal. 2024;22:373. 10.1186/s12964-024-01756-x
Isola S, Gammeri L, Furci F, Gangemi S, Pioggia G, et al. Vitamin C Supplementation in the Treatment of Autoimmune and Onco-Hematological Diseases: From Prophylaxis to Adjuvant Therapy. Int J Mol Sci. 2024;25. 10.3390/ijms25137284
Ali A, Jori C, Kumar A, Vyawahare A, Kumar J, et al. A bioactive and biodegradable vitamin C stearate-based injectable hydrogel alleviates experimental inflammatory arthritis. Biomater Sci. 2024;12:3389. 10.1039/d4bm00243a
Zhang Y, Zhen S, Xu H, Sun S, Wang Z, et al. Vitamin C alleviates rheumatoid arthritis by modulating gut microbiota balance. Biosci Trends. 2024;18:187. 10.5582/bst.2024.01037
Zhang L, Li G, Lin B, He H, Zhou R, et al. Ascorbyl palmitate ameliorates inflammatory diseases by inhibition of NLRP3 inflammasome. Int Immunopharmacol. 2024;131:111915. 10.1016/j.intimp.2024.111915
Santiworakul C, Saisorn W, Siripen N, Leelahavanichkul A, Rianthavorn P. Interleukin-8 and neutrophil extracellular traps in children with lupus nephritis and vitamin C deficiency. Pediatr Nephrol. 2024;39:1135. 10.1007/s00467-023-06189-1
Mungan S, Guzel I, Demirdogen BC. Association between Expanded Disability Status Scale score and dietary antioxidant capacity in patients with multiple sclerosis. Braz J Med Biol Res. 2023;56:e12776. 10.1590/1414-431X2023e12776
Farasati Far B, Behnoush AH, Ghondaghsaz E, Habibi MA, Khalaji A. The interplay between vitamin C and thyroid. Endocrinol Diabetes Metab. 2023;6:e432. 10.1002/edm2.432
Ueki M, Sakamoto K, Nishioka N, Ohata H, Nobuta T, et al. Rheumatologic manifestations with elevated levels of IL-6, IL-17A, and IL-23 in a patient with scurvy. Mod Rheumatol Case Rep. 2023;7:302. 10.1093/mrcr/rxac059